Table 4.

Comparison of logD at pH 2.5 and 7.4 for FC101a analogs

Analog	pH 2.5	Solubility (pH 2.5)	pH 7.4	Solubility (pH 7.4)
FC101 Oxazole	2.25	Lipophilic	2.35	Lipophilic
FC101b	1.04	Lipophilic	1.04	Lipophilic
FC101 Imidazole	−0.55	Hydrophilic	2.11	Lipophilic
FC101 Formyl	−1.3	Hydrophilic	0.75	Lipophilic
FC101N	−1.1	Hydrophilic	−0.53	Hydrophilic
FC101i	−1.78	Hydrophilic	0.17	Lipophilic
FC101L	−2.11	Hydrophilic	−2.11	Hydrophilic
FC101 Acetonide R	−0.66	Hydrophilic	1.67	Lipophilic
FC101 dehydroxyl	−0.91	Hydrophilic	0.06	Lipophilic
Kynurenine B	−2.27	Hydrophilic	−2.2	Hydrophilic
FC101K	−1.91	Hydrophilic	−0.03	Hydrophilic
FC101a	−1.69	Hydrophilic	−0.53	Hydrophilic
FC101M	−1.02	Hydrophilic	−0.76	Hydrophilic
FC101 Phos	−1.02	Hydrophilic	−0.9	Hydrophilic

Most analogs are hydrophilic, indicating a water-soluble nature. Some analogs like FC101 Oxazole are lipophilic and thus would more readily penetrate the lipid bilayer