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. 2015 Jun 1;9(Suppl 3):S4. doi: 10.1186/1752-0509-9-S3-S4

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Copyright © 2015 Alaimo et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DT-Web Drug Combination Prediction Example. Once the user submits a list of genes, DT-Web calculates, using the pathways stored in the database, a list of possible drugs that indirectly target such genes, using the pipeline described above. When finished, the user will see a list of such drugs, ordered by direct and indirect targets, which can be filtered by selecting an appropriate combination of parameters (either one or more drugs/targets). By selecting a drug or a target, the user will also view an excerpt of the pathway used by the algorithm to compute the prediction. By clicking on a drug the user obtains a list of predicted targets.