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. 2015 Jun 12;14:83. doi: 10.1186/s12934-015-0272-y

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© Li et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Scale-up bioprocess development for valinomycin production in E. coli from 1 mL to 10 L. a A representative well from the 24-well plates, which are incorporated with sensors allowing online measurement of oxygen and pH. Cultivations were performed in 24-well plates with 1 mL working volume per well (total volume 3.3 mL); b cultivations were performed in 500 mL shake flasks with 100 mL working volume; c cultivation was performed in a 3.7 L bioreactor with 2 L working volume; d cultivations were performed in a 15 L scale-down TCR with 10 L working volume. STR stirred tank reactor, PFR plug flow reactor.