Table 1.
The 10 most significant SoC-associated DMRs (SoC-DMRs) identified by the bump hunting analysis
| Chr | SoC-DMR start | SoC-DMR end | Mean coefficient | Probes in SoC-DMR | Probes in cluster | SoC P -value | SoC P -value (FWER) | Gene | Annotation |
|---|---|---|---|---|---|---|---|---|---|
| 5 | 135,415,762 | 135,416,613 | 0.61 | 15 | 15 | 2.0E-05 | 0.009 | VTRNA2-1 | Overlaps TSS |
| 2 | 113,992,762 | 113,993,313 | 0.47 | 8 | 8 | 5.5E-04 | 0.228 | PAX8* | Intron/exon |
| 5 | 23,507,030 | 23,507,752 | 0.36 | 12 | 13 | 8.7E-04 | 0.349 | PRDM9 | Overlaps TSS |
| 6 | 32,729,442 | 32,729,847 | 0.14 | 20 | 36 | 1.6E-03 | 0.576 | HLA-DQB2 | Intron/exon |
| 17 | 17,109,570 | 17,110,120 | 0.38 | 8 | 11 | 1.8E-03 | 0.578 | PLD6 | Overlaps TSS |
| 6 | 29,648,345 | 29,649,024 | 0.27 | 14 | 18 | 1.8E-03 | 0.601 | ZFP57* | ~3 kb upstream of TSS |
| 6 | 151,646,312 | 151,647,133 | 0.30 | 9 | 9 | 2.8E-03 | 0.733 | AKAP12 | Overlaps TSS |
| 12 | 57,040,045 | 57,040,204 | 0.36 | 4 | 9 | 3.2E-03 | 0.782 | ATP5B* | Promoter |
| 5 | 191,242 | 192,103 | 0.26 | 10 | 11 | 3.8E-03 | 0.848 | LRRC14B | Overlaps TSS |
| 13 | 36,944,640 | 36,944,649 | 0.36 | 2 | 8 | 4.4E-03 | 0.864 | SPG20 | Promoter |
Analysis includes adjustment for sex and estimated white blood cell composition. Gene annotations are those provided by Illumina, except for entries marked with an asterisk, for which overlapping or proximal genes are listed. TSS, transcription start site.