Table 3.

Univariate and multivariate Cox proportional hazards models for OS and PFS

	OS		PFS
Variable	Relative risk	P	Relative risk	P
Univariate
Age	1.00	0.84	1.01	0.81
Haemoglobin	1.13	0.41	1.15	0.33
Calcium	1.04	0.84	0.76	0.23
Performance status = 1	0.63	0.29	0.74	0.47
Pathology = mixed	0.75	0.54	0.58	0.20
No. organs involved ≥ 2	0.92	0.86	0.85	0.74
Metastasis in lung	0.51	0.08	0.46	0.04
Metastasis in lymph node	2.00	0.09	1.67	0.20
Metastasis in renal bed	1.33	0.54	1.84	0.19
Metastasis in bone	1.08	0.90	1.28	0.69
Metastasis in other	0.77	0.73	0.74	0.69
Therapy before surgery = No IL-2	0.64	0.25	0.66	0.26
Therapy duration, months	0.97	0.62	1.01	0.90
Log (time first diagnosis to mets)	1.17	0.19	1.13	0.24
Log (time mets to surgery)	1.36	0.48	1.37	0.42
No. sites of surgery ≥ 2	0.98	0.97	0.87	0.83
Lung at surgery	0.64	0.25	0.59	0.16
Lymph node at surgery	1.79	0.16	1.60	0.25
Renal bed at surgery	1.21	0.70	1.57	0.37
Bone at surgery	1.08	0.90	1.28	0.69
Other at surgery	0.47	0.47	0.39	0.36
Not NED after surgery	7.02	< 0.001	8.71	< 0.001
Multivariate
Not NED after surgery	6.06	< 0.001	13.98	< 0.001
Metastasis in lung	0.62	0.003	0.30	0.003

met, metastases.