Table 1.
Baseline characteristics by HER2 status in 458 women with a primary DCIS
| Characteristics | All | HER2 positive | HER2 negative | HER2 missing | |
|---|---|---|---|---|---|
| (n = 458) | (n = 132) | (n = 288) | (n = 38) | ||
| n (%) | n (%) | n (%) | P-valuea | n (%) | |
| Age (years) mean (n = 458) | 58.6 | 57.4 | 59.2 | 0.13 | 58.8 |
| Detection mode (n = 457) | |||||
| Screening | 345 (75.5 %) | 108 (81.8 %) | 210 (73.2 %) | 27 (71.1 %) | |
| Clinically | 112 (24.5 %) | 24 (18.2 %) | 77 (26.8 %) | 0.05 | 11 (28.9 %) |
| Type of Surgery (n = 457) | |||||
| BCS | 359 (78.6 %) | 98 (74.2 %) | 233 (81.2 %) | 28 (73.7 %) | |
| Mastectomy | 98 (21.4 %) | 34 (25.8 %) | 54 (18.8 %) | 0.11 | 10 (26.3 %) |
| Radiotherapy (n = 359) | |||||
| Yes | 158 (44.0 %) | 49 (50.0 %) | 100 (42.9 %) | 9 (32.1 %) | |
| No | 201 (56.0 %) | 49 (50.0 %) | 133 (57.1 %) | 0.32 | 19 (67.9 %) |
| Tumor size (mm) (n = 409) | |||||
| ≤ 25 | 294 (71.9 %) | 68 (61.3 %) | 203 (77.2 %) | 23 (65.7 %) | |
| > 25 or multifocal | 115 (28.1 %) | 43 (38.7 %) | 60 (22.8 %) | 0.002 | 12 (34.3 %) |
| Nuclear grade (n = 458) | |||||
| Grade 1 | 42 (9.2 %) | 1 (0.8 %) | 34 (11.8 %) | 7 (18.4 %) | |
| Grade 2 | 176 (38.4 %) | 20 (15.1 %) | 145 (50.3 %) | 11 (28.9 %) | |
| Grade 3 | 240 (52.4 %) | 111 (84.1 %) | 109 (37.8 %) | <0.001 | 20 (52.6 %) |
| ER status (n = 419) | |||||
| Positive | 307 (73.3 %) | 59 (45.7 %) | 243 (86.5 %) | 5 (55.6 %) | |
| Negative | 112 (26.7 %) | 70 (54.3 %) | 38 (13.5 %) | <0.001 | 4 (44.4 %) |
| PR status (n = 409) | |||||
| Positive | 213 (52.1 %) | 35 (28.2 %) | 175 (62.9 %) | 4 (57.1 %) | |
| Negative | 196 (47.93 %) | 89 (71.8 %) | 103 (37.1 %) | <0.001 | 3 (42.9 %) |
BCS breast conserving surgery, RT postoperative radiotherapy
aComparisons between HER2-negative and HER2-positive DCIS were made by χ2-test, except for age and size that was compared by T-test