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. 2015 May 23;15:24. doi: 10.1186/s12902-015-0017-2

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© Zhang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Role of HIF-1α in protecting AtT-20 cells from hypoxia-induced apoptosis. AtT-20 cells were transfected with 10 μM HIF-1α siRNA or mock transfected, and subsequently cultured in hypoxic or normoxic conditions for 12h. (a) Annexin V-FITC and (b) TUNEL assay showed increased apoptosis when cells were transfected with HIF-1α siRNA and subsequently cultured in 1% O₂ for 12 h compared with normoxia and mock groups (*P < 0.05 vs.the other groups)