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. 2015 May 23;15:24. doi: 10.1186/s12902-015-0017-2

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© Zhang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Downregulation of GR by dexamethasone under hypoxia conditions was HIF-1α-dependent. Under normoxia or hypoxic incubation for 12h, mRNA and protein expression levels of HIF-1α (a,c), GR (b,c) in cells transfected with HIF-1α-siRNA compared to nontransfected cells after dexamethasone treatment (24h). (d) Quantification of (c) (*P < 0.05 vs siRNA)