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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Exp Neurol. 2015 Feb 14;266:42–54. doi: 10.1016/j.expneurol.2015.02.008

Figure 1. Schematic representation of the experimental design.

Figure 1

Rats received unilateral 6-OHDA injection into the medial forebrain bundle and were allowed to recover for 3 weeks before being randomly assigned to the SALINE or L-DOPA treatment groups. Rats from the L-DOPA group were pretested for apomorphine-induced rotations once and then for L-DOPA-induced rotations for 5 days. Following pretesting, rats of both SALINE and L-DOPA groups were assigned to GFP or GRK6 groups and received unilateral injections of respective lentiviruses into the lesioned dorsolateral caudate-putamen as described in Methods. Following 5-day recovery period, rats were tested for L-DOPA-induced rotations (L-DOPA group) or treated with saline (SALINE group) for 10 days. Approximately 14 h after the last injection, the rats of each group were randomly challenged with either saline or L-DOPA and sacrificed 45 min later. The design produced 8 experimental groups; N – number of rats in each group.