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. Author manuscript; available in PMC: 2016 May 19.
Published in final edited form as: Neurosci Lett. 2015 Apr 3;595:1–6. doi: 10.1016/j.neulet.2015.04.002

Figure 1. Intrathecal JWH-133 suppresses mechanical and cold hypersensitivity in a dose-dependent manner.

Figure 1

The CB2-selective agonist JWH-133 was intrathecally (i.t.) administered 24–28 d (4 wk) after induction of EAE in C57/B6 mice. Time course and area under the curve (AUC) analysis of mechanical (A,C) and cold (B,D) hypersensitivity after JWH-133. Dose-response analysis of the data at 60 min for mechanical (E) and cold hypersensitivity (F), respectively. MPE: maximum possible effect. Parentheses refer to number of animals per group. †p < 0.05 50 μg vs vehicle; ‡p < 0.05 100 μg vs vehicle; ★p < 0.05 vs vehicle.