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Spinal cord MOR signaling, through inhibitory Gai/o proteins, tonically represses AC1 production of cAMP, thereby reducing nociceptive signal transduction. Blockade of MOR results in the disinhibition of AC1, allowing for NMDAR-derived, Ca2+-mediated activation and downstream increases in signal transduction, neuron excitability, and ultimately, pain. Adapted from Corder et al, 2013.
