Table 2.
miRNA Name | Cytoband | Predicted Targetsc |
---|---|---|
hsa-miR-484 | 16p13.11 | ● |
hsa-miR-617 | 12q21.31 | ● |
hsa-miR-3179 | 16p13.11 | ● |
hsa-miR-3180d | 16p13.11 | ● |
hsa-miR-3180-3p, hsa-miR-3180-5pd | 16p13.11 | ● |
hsa-miR-3670 | 16p13.11 | ● |
hsa-miR-3680-3p, hsa-miR-3680-5p | 16p11.2 | |
hsa-miR-4435 | 2q13 | ● |
hsa-miR-4507 | 14q32.33 | |
hsa-miR-4508 | 15q11-15q13 | |
hsa-miR-4509 | 15q11-15q13 | ● |
hsa-miR-4537 | 14q32.33 | |
hsa-miR-4538 | 14q32.33 | ● |
hsa-miR-4539 | 14q32.33 | ● |
hsa-miR-4715-3p, hsa-miR-4715-5p | 15q11-15q13 | ● |
hsa-miR-4752 | 19q13.42 | ● |
hsa-miR-4771e | 2p11.2 and 2q13 | ● |
hsa-miR-5087 | 1q21.1 | |
hsa-miR-6506-3p, hsa-miR-6506-5p | 16p13.11 | |
hsa-miR-6511a-3p, hsa-miR-6511a-5p | 16p13.11 |
CNV, copy number variant; miRNA, microRNA.
See Table S2 in Supplement 1 for additional details, including relevant CNV coordinates.
All miRNAs overlapped by CNVs in n = 2 unrelated probands except for hsa-miR-3680-3p, hsa-miR-3680-5p (n = 4); hsa-miR-4435 (n = 3); hsa-miR-4508 (n = 3); hsa-miR-4715-3p, hsa-miR-4715-5p (n=3); and hsa-miR-4771 (n = 4).
See Methods and Materials for details. Our stringent criteria (97th percentile target prediction score and with genes predicted by two of three established tools) and the lack of available data for many miRNAs (e.g., miRNAs numbered above 5000) resulted in many miRNAs not having a reliable list of target genes.
As detailed in miRBase, hsa-miR-3180, hsa-miR-3180-3p, and hsa-miR-3180-5p are distinct mature miRNAs.
As detailed in miRBase, hsa-miR-4771 is a mature miRNA located at two different cytobands: 2p11.2 and 2q13.