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. 2015 Jun 6;12:113. doi: 10.1186/s12974-015-0326-4

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© Sarada et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Protein expression pattern of NF-κB and related genes in the brain homogenate of rats exposed to hypobaric hypoxia for 24 h at 7620 m. a Representing Western blot analysis of (i) NF-κB, (ii) IL-1, (iii) IL-18, (iv) TNF-α, (v) P-selectin and (vi) E-selectin proteins in the brain of rats under hypoxia. b Depicts the NF-κB-DNA-binding activity. Nuclear extracts were prepared and used to analyse the NF-κB-DNA binding by EMSA. The arrow indicates the position of NF-κB and free probe. The enhanced NF-κB and its downstream genes were downregulated by curcumin treatment prior to hypoxia exposure. The densitometry analyses were represented below their respective analyses. Values are mean ± SD (n = 6). ^a p < 0.001 compared with normoxia (0 h) group; ^b p < 0.001 compared with hypoxia (24 h) group; ^c p < 0.05 compared with normoxia (0 h) group; ^d p < 0.05 compared with hypoxia (24 h) group. Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)