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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Reprod Toxicol. 2014 Dec 29;54:110–119. doi: 10.1016/j.reprotox.2014.12.013

Table 1.

Experimental plan of EDC treatment for “nulliparous” and “parous” female Sprague-Dawley rats. Animals are treated from PND 1 to PND 181.

Group Compounda Animals
 Treatmentb
Status No. Dose (mg/Kg b.w.)
I DEP Nulliparous/virgin 10 0.1735
II Parous 10
III MPB Nulliparous/virgin 10 0.1050
IV Parous 10
V TCS Nulliparous/virgin 10 0.050
VI Parous 10
VII MIX Nulliparous/virgin 10 Mixture of DEP+MPB+TCS
VIII Parous 10
IX OILc Nulliparous/virgin 10 -
X Parous 35d
Total 125
a

DEP (Diethylphtalate, CAS 84-66-2), MPB (Methylparaben, CAS 99-76-3), TCS (Triclosan, CAS 3380-34-5), MIX (mixture of DEP+MPB+TCS in equal quantity), OIL (olive oil control, vehicle alone)

b

Animals were treated from PND1 to PND181. Three dams for each parous group are sacrificed at the end of lactation at LD 28 and 3 nulliparous age-matched ones are sacrificed at the same time (PND 146). Each compound was administered in olive oil as vehicle by gastric intubation (gavage), starting with 0.5 ml of olive oil from 4 to 9 weeks of age, and then with 1 ml once adult.

c

Control animals from different control groups

d

The animals serve as concurrent control groups, in common with other studies