Table 1.
Inherited human diseases of accelerated aging.
Progeroid syndrome | Tissues affected | Genome maintenance system altered | References |
---|---|---|---|
Xeroderma pigmentosum | skin cancer premature aging of the epidermal,central nervous system |
nucleotide excision repair | (Kraemer and DiGiovanna 2014) |
Cockayne syndrome | premature aging of the central nervous, adipose and musculoskeletal systems | transition-coupled nucleotide excision repair | (Nance and Berry 1992) |
Trichothiodystrophy | aged appearance | transition-coupled repair nucleotide excision | (Bootsma D. and others 1998) |
Ataxia telangiectasia | Cancer premature aging of the central nervous and endocrine systems |
double-strand break repair | (Chun and Gatti 2004) |
AT-like disorder | premature aging of the central nervous and endocrine systems | double-strand break repair | (Chun and Gatti 2004) |
Werner's syndrome | Cancer premature aging of the cardiovascular, musculoskeletal, epidermal, endocrine and ocular systems |
telomere maintenance | (Kudlow and others 2007) |
Fanconi anemia | Cancer premature aging of the bone marrow |
interstrand crosslink repair | (Auerbach 2009) |
Hutchinson-Gilford | premature aging of the cardiovascular, musculoskeletal and reproductive systems | chromatin organization; timely repair of double-strand breaks | (Kudlow and others 2007) |
XFE progeroid syndrome | systemic premature aging | nucleotide excision repair, interstrand crosslink repair, repair of some strand breaks with 3′ flaps | (Niedernhofer and others 2006) |