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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Exp Gerontol. 2015 Jan 21;68:43–50. doi: 10.1016/j.exger.2015.01.045

Table 1.

Inherited human diseases of accelerated aging.

Progeroid syndrome Tissues affected Genome maintenance system altered References
Xeroderma pigmentosum skin cancer
premature aging of the epidermal,central nervous system
nucleotide excision repair (Kraemer and DiGiovanna 2014)
Cockayne syndrome premature aging of the central nervous, adipose and musculoskeletal systems transition-coupled nucleotide excision repair (Nance and Berry 1992)
Trichothiodystrophy aged appearance transition-coupled repair nucleotide excision (Bootsma D. and others 1998)
Ataxia telangiectasia Cancer
premature aging of the central nervous and endocrine systems
double-strand break repair (Chun and Gatti 2004)
AT-like disorder premature aging of the central nervous and endocrine systems double-strand break repair (Chun and Gatti 2004)
Werner's syndrome Cancer
premature aging of the cardiovascular, musculoskeletal, epidermal, endocrine and ocular systems
telomere maintenance (Kudlow and others 2007)
Fanconi anemia Cancer
premature aging of the bone marrow
interstrand crosslink repair (Auerbach 2009)
Hutchinson-Gilford premature aging of the cardiovascular, musculoskeletal and reproductive systems chromatin organization; timely repair of double-strand breaks (Kudlow and others 2007)
XFE progeroid syndrome systemic premature aging nucleotide excision repair, interstrand crosslink repair, repair of some strand breaks with 3′ flaps (Niedernhofer and others 2006)
HHS Vulnerability Disclosure