. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Xenotransplantation. 2015 Apr 3;22(3):211–220. doi: 10.1111/xen.12167

Table 1.

Details of Group A and B experiments

Baboon #	Pig	Immuno- suppressive Regimen^*	Graft/Recipient Survival (days)	Complications	Cause of Termination (graft score)
Group A (all received GTKO.CD46.CD55 pig hearts)
B 19110		1	33	Hemorrhage ^(a) Left hemiplegia ^(b)	Euthanized (1/3)
B 19010		1	18	Massive ascites ^(c)	Euthanized (1/3)

B 19510		2	15	Ascites Septic peritonitis ^(d)	Died (2/3)
B 18910		2	23	Septicemia/ascites ^(e)	Euthanized (1.5/3)

Group B (all received GTKO.CD46.TBM pig hearts)^**
B 5512	TBM (8%) (pig TBM promoter)	3	99	CMV pneumonia	Euthanized (2.5/3)
B 5712	TBM (26%) (pig TBM promoter)	3	130	None	Graft failure (0.5/3)

B 16311	TBM (96%) (ICAM-2 promoter/enhancer)	1	52	Pneumonia ^(f)	Euthanized (3/3)

For details, see Table 2.

^**

Percentage refers to percentage of donor pig AECs expressing human TBM.

^(a)

Related to high heparin dosage; treated successfully.

^(b)

Intra-arterial catheter thromboembolic complication.

^(c)

Ascites drained on two occasions (day 14 = 500 mL and day 16 = 750 mL); reaccumulated rapidly; ascitic fluid sterile.

^(d)

Blood - enterococcus faecalis; ascites drained at necropsy (day 15 = 600 mL); ascitic fluid also grew enterococcus faecalis.

^(e)

Blood - enterococcus faecalis; ascites drained on day 14 (<50 mL) and at necropsy (day 23 = 700 mL); ascitic fluid sterile.

^(f)

This baboon did not receive anti-CD20mAb. Pneumonia related to Enterococcus faecalis and Escherischia coli.