DAMGO antinociception in brain P450-deficient mice following intrathecal (i.t.) administration. Control (WT) and Null mice were tested for nociceptive responses (baseline, BL), received either saline or DAMGO (0.1 nmol), and were re-tested at the indicated times (abscissa, min). Ordinate shows latencies (pooled sexes, sec, mean ± S.E.M.) for the n values in parentheses. **P < 0.01 respectively vs. Saline at the same time in the same genotype.