Table 5.
Differences in study measures between participants s with and without skin-biopsy diagnosis of SFPN (n=66)
| ENF density < 5% (SFPN) | ENF density > 5% (not SFPN) | ||||
|---|---|---|---|---|---|
| COMPASS 31 | Median (N=28) | Median (N=38) | U | Z | P value |
| Total score | 38.8 | 19.6 | 278 | −3.296 | 0.001* |
| Orthostatic intolerance | 22.0 | 6.0 | 265.5 | −3.571 | <0.001* |
| Vasomotor | 1.7 | 0.0 | 395.5 | −2.041 | 0.041 |
| Secretomotor | 6.4 | 2.1 | 378.5 | −2.048 | 0.041 |
| Gastrointestinal | 7.1 | 5.4 | 408 | −1.613 | 0.107 |
| Bladder | 1.1 | 0.0 | 399 | −1.93 | 0.054 |
| Pupillomotor | 2.2 | 1.0 | 329 | −2.662 | 0.008 |
| SF-36 | |||||
| Total score | 33.1 | 77.9 | 205.5 | −3.997 | <0.001* |
| Physical health | 27.5 | 82.2 | 184 | −4.291 | <0.001* |
| Mental Health | 44.5 | 79.3 | 217 | −3.840 | <0.001* |
| SF-McGill-2 | |||||
| Total score | 3.7 | 0.5 | 216 | −4.104 | <0.001* |
| Continuous pain | 4.0 | 0.7 | 225 | −3.994 | <0.001* |
| Intermittent pain | 2.7 | 0.0 | 270.5 | −3.468 | 0.001* |
| Neuropathic pain | 3.2 | 0.5 | 255.5 | −3.610 | <0.001* |
| Affective descriptors | 3.0 | 0.0 | 137 | −3.773 | <0.001* |
| Pain score (NPS) | 6.0 | 1.0 | 238.5 | −3.443 | 0.001* |
| Autonomic Function Testing (CASS) | |||||
| Total score | 3 | 1.5 | 378.5 | −2.031 | 0.046 |
| Cardiovagal | 0 | 0 | 475 | −0.843 | 0.399 |
| Adrenergic | 0 | 0 | 487.5 | −0.382 | 0.703 |
| Sudomotor | 2 | 0 | 351.5 | −2.320 | 0.020 |
P values below 0.0025 are considered significant and marked with * (Bonferroni corrections for 20 comparisons). SF-MPQ-2- The short-form McGill pain questionnaire; SF-36- Short Form Health Survey; NPS- Numeric pain scale.