Table 1.

Impact of ERα genotype on lymphocyte activation in female B6.Sle1 mice^a

	B6		B6.Sle1
Cell type	ERα +/+	−/−	+/+	−/−
B220+b	54.7±2.0	55.2±3.1	49.1±2.4e	49.3±2.7
B220+CD86+c	8.6±1.3	9.3±2.5	12.9±2.5e	6.2±1.4g
CD4+b	17.2±1.0	18.2 ±1.3	17.8±0.8	17.8±1.2
CD4+CD69+d	13.3±2.3	12.8±4.3	22.6±3.2f	8.8±1.4g
CD4+CD134+d	13.5±3.6	9.4±3.8	24.8±4.1e	11.9±3.2f
CD4+CD62L+d	40.6±4.7	59.2±4.7g	15.0±1.4f	25.2±5.2f,g
CD4+CD25+d	2.4±0.2	2.7±0.2	1.9±0.2e	1.9±0.3e

^aSplenocytes from each mouse (6-12 months of age) were analyzed individually by flow cytometry (N=12-24 per group). The values presented represent the mean ± SEM for the samples in each group.

^bValues represent the mean percentage of total splenocytes.

^cValues represent the mean percentage of B220⁺ splenocyte

^dValues represent the mean percentage of CD4⁺ splenocytes.

^eSignificant difference compared to B6 mice of the same ERα genotype are denoted by (P≤0.05)

^fSignificant difference compared to B6 mice of the same ERα genotype are denoted by (P≤0.01)

^gSignificant difference compared to ERα^+/+ mice of the same Sle1 genotype are denoted by (P≤0.01)