Table 3.
Impact of ERα genotype on lymphocyte activation male B6.Sle1 micea
| B6 |
B6.Sle1 |
|||
|---|---|---|---|---|
| Cell type | ERα +/+ | −/− | +/+ | −/− |
| B220+b | 57.3±2.2 | 52.9±3.7 | 58.6±2.0 | 59.4±2.2 |
| B220+CD86+c | 6.8±1.1 | 6.6±1.8 | 7.0±2.2 | 7.9±2.2 |
| CD4+b | 15.6±1.9 | 15.9±1.7 | 16.2±0.7 | 15.2±0.9 |
| CD4+CD69+d | 17.6±2.7 | 14.7±3.4 | 25.5±2.5 | 15.0±3.9f |
| CD4+CD134+d | 17.8±3.4 | 21.3±6.4 | 25.7±3.4 | 15.3±4.6 |
| CD4+CD62L+d | 52.9±6.9 | 55.9±6.3 | 31.4±3.0e | 33.7±4.6e |
| CD4+CD25+ | 2.3±0.2 | 2.5±0.3 | 2.2±0.1 | 2.3±0.2 |
a
Splenocytes from each mouse (6-12 months of age) were analyzed individually by flow cytometry (N=14-32 per group). The values presented represent the mean ± SEM for the samples in each group.
b
Values represent the mean percentage of total splenocytes.
c
Values represent the mean percentage of B220+ splenocytes
d
Values represent the mean percentage of CD4+ splenocytes.
e
Significant differences compared to Sle1B/B mice of same gender and ERα genotype are denoted by (P≤0.01)
f
Significant difference compared to ERα+/+mice of same gender and Sle1 genotype are denoted by (P≤0.05)