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. Author manuscript; available in PMC: 2016 Jun 9.
Published in final edited form as: Cell Rep. 2015 May 28;11(9):1385–1399. doi: 10.1016/j.celrep.2015.04.062

Figure 7.

Figure 7

Gene expression gradients in organ of Corti hair cells. (A) Genes expected to be expressed in mature hair cells including Otof (Otoferlin), Clrn1 (Clarin1) and Ptprq show increasing expression levels from apex to base. (B) Calcium binding proteins Calb1 (Calbindin), Calb2 (Calretinin) and Ocm (Oncomodulin) are expressed in gradients with the same orientation, (C) as shown for calcium channel Cacna1d (CaV1.3) as well. (D) Hair bundle genes like Actb (beta-Actin), Myo15 (Myosin15) and Pcdh15 (Protocadherin 15) are significantly higher expressed in the apex compared to the base. The same pattern is present for four transcription factor genes (Isl1, Dach1, Eya2 and Pax2).