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. Author manuscript; available in PMC: 2015 Jun 13.
Published in final edited form as: Curr Biol. 2014 Jan 20;24(2):R80–R82. doi: 10.1016/j.cub.2013.11.052

Figure 1.

Figure 1

X chromosome topology directs Xist localization.

(A) Xist RNA (red) utilizes 3D contacts to localize to distal sites. (B) Model 1: the Xic samples the entire X over time and Xist RNA (red and blue at different time points) accumulation is determined by the affinity of Xist RNA for chromatin features at each region. (C) Model 2: Xist RNA (red) alters contact sites such that they have greater affinity for subsequently produced Xist RNA (blue), promoting its spread in cis along the X.