Table 2. Emerging Paradigms Linking Epigenetic Factors and Mechanisms With Diverse Neurological Disease Processes.

Paradigms
Mutations in genes encoding epigenetic factors cause disease
Genetic variations in genes encoding epigenetic factors modify disease risk
Abnormalities in epigenetic factor expression, localization, or function are involved in disease pathophysiology
Epigenetic mechanisms regulate disease-associated genomic loci, gene products, and cellular pathways
Differential epigenetic profiles are present in patient-derived central and peripheral tissues