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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: DNA Repair (Amst). 2015 Apr 25;31:41–51. doi: 10.1016/j.dnarep.2015.04.006

Fig. 1.

Fig. 1

Mutation rates and fidelity factors for base selectivity, proofreading, and MMR on both the leading and lagging strands. (A) Mutation rates were measured at the agp1::URA3-OR1 locus in WT, pol2-exo-, pol3-exo-, msh6Δ, pol2-exo- msh6Δ, and pol3-exo- msh6Δ strains. Please note that the y-axis is on a logarithmic scale. (B) The apparent fidelity factors for base selectivity, proofreading, and MMR are depicted for the leading strand (dark gray) and the lagging strand (light gray). The y-axis values are number of correctly replicated or repaired bases per mutation and is on a logarithmic scale. The lines within the bars for base selectivity indicate the base selectivity of Pol ε[46] and Pol δ [45] measured in vitro.