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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Mol Cell. 2015 May 28;58(5):722–728. doi: 10.1016/j.molcel.2015.05.023

Figure 3. Tail subunits participate in the destruction of DNA targets.

Figure 3

(A) Type I and Type III surveillance complexes share a multi-subunit sea-horse-shaped architecture. The tail subunits of both Types are involved in DNA cleavage. The Cse1 protein of Type I complexes recruit the trans-acting nuclease Cas3 for DNA cleavage, and the Csm2 protein of Type III complexes is critical for DNA target degradation. (B) Structural comparison of the distinct tail subunits (PDB 4TVX and 4W8Y). (C) Close-up of the conserved the GGDD motif and a coordinated manganese ion (green). (D) Closeup of the histidine-aspartate (HD)-motif and two manganese ions (green) in the N-terminal domain.