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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Int J Cancer. 2014 Sep 29;136(5):E242–E251. doi: 10.1002/ijc.29198

Fig.4.

Fig.4

Phase contrast microscopy of C8161 and DNC8161 melanoma cells exhibit distinct cellular morphology on different matrices. C8161 cells grown on plastic substrate generate VM networks (4A, arrows), while DN C8161 cells fail to do so and remain as a monolayer (4B). Likewise, when plated on Matrigel, C8161 cells formed ECM-rich capillary-like network structures (4C), while their DN C8161 counterpart grows in clumps and forms aggregates (4D). Long term cultures of C8161 on 3D Collagen I resulted in the formation of more developed tubular structures (4E, arrows), while DN C8161 cells fail to form any structures (4F). Original magnification, 10×.