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. Author manuscript; available in PMC: 2015 Jun 14.
Published in final edited form as: Nat Rev Neurosci. 2013 May 30;14(7):502–511. doi: 10.1038/nrn3516

Figure 2. Afferent pain pathways include multiple brain regions.

Figure 2

Afferent nociceptive information enters the brain from the spinal cord. Afferent spinal pathways include the spinothalamic, spinoparabrachio–amygdaloid and spinoreticulo–thalamic pathways. Nociceptive information from the thalamus is projected to the insula, anterior cingulate cortex (ACC), primary somatosensory cortex (S1) and secondary somatosensory cortex (S2), whereas information from the amygdala (AMY) is projected to the basal ganglia (BG). See the main text for references. PAG, periaqueductal grey; PB, parabrachial nucleus; PFC, prefrontal cortex.