Fig. 1.

Mechanical allodynia develops on ipsilateral hindpaw post CCI surgery: The mechanical allodynia is represented as normalized difference scores between the baseline values before the surgery and day 11 post-surgery for three treatment groups; naïve control, sham control and CCI rats. More negative scores represent higher mechanical sensitivity towards Semmes-Weinstein filaments. CCI rats developed mechanical allodynia and were significantly different from both sham and naïve control groups. Bars represent the mean ± SEM and * represents significant difference at p ≤ 0.05 (Kruskal–Wallis 1-way ANOVA by ranks). Sample size for each treatment group is indicated on the graph.