Fig. 3.

Dynamic Bayesian Network (DBN) inference suggests a central role for the inflammasome in CCI: Data on inflammatory mediators from CCI (A) and sham (B) rats (see Fig. 2 & Extended Data Table 1) were used to carry out DBN inference. Inflammatory mediators are represented as network nodes. The thickness of connections among nodes or to themselves (edges) is thicker based on how often they are represented in individual experiments. Nodes with auto-regulatory feedback and connections to other nodes are considered central.