Extended Data Table 1.
Results in pg/mg protein | ||||||||||||||||
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Sample ID | Sample | Time Point of tissue collection (hrs.) | IL-5 | MCP-1 | TNF-α | IL-1β | IL-6 | GM-CSF | GRO/KC | IFN-γ | IL-1α | IL-10 | IL-12p70 | IL-18 | IL-2 | IL-4 |
Baseline | Baseline-1 | 0 | 26.02 | 86.8 | 6.06 | 272.13 | 164.04 | 10.58 | 8.16 | 277.18 | 31.72 | 38.32 | 32.29 | 207.14 | 114.97 | 174.14 |
Baseline-2 | 0 | 20.86 | 129.14 | 1.11 | 164.04 | 214.59 | 0 | 4.76 | 422.55 | 18.06 | 5.08 | 31.04 | 176.91 | 86.98 | 50.51 | |
Baseline-3 | 0 | 23 | 208.26 | 14.95 | 264.41 | 333.79 | 11.85 | 30.12 | 543.56 | 28.39 | 30.89 | 33.52 | 249.61 | 121.2 | 44.38 | |
Baseline-4 | 0 | 19.73 | 86.8 | 1.11 | 189.08 | 214.59 | 9.3 | 9.82 | 298.79 | 37.44 | 3.46 | 31.04 | 132.45 | 126.58 | 22.82 | |
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Sham Day 0 |
Sham (0)1 | 2 hr. | 21.95 | 2533.15 | 10.15 | 546.64 | 6841.53 | 14.35 | 901.84 | 243.7 | 19.83 | 20.07 | 28.45 | 203.36 | 107.94 | 49.64 |
Sham (0)2 | 2 hr. | 19.73 | 1454.84 | 0 | 240.43 | 7285.84 | 3.9 | 3208.15 | 228.9 | 34.19 | 50.31 | 31.04 | 93.37 | 144.85 | 117.41 | |
Sham (0)3 | 2 hr. | 26.02 | 1490.07 | 6.83 | 530.11 | 5466.47 | 14.35 | 1658.14 | 392.1 | 21.57 | 61.76 | 32.29 | 262.91 | 117.19 | 47.04 | |
Sham (0)4 | 2 hr. | 20.86 | 2736.26 | 9.84 | 588.89 | 5485.88 | 8.65 | 1482.66 | 253.41 | 22.44 | 42.41 | 29.76 | 320.89 | 101.86 | 68.44 | |
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Sham Day 8 |
Sham (8)1 | 192 hr. | 24.03 | 86.8 | 7.56 | 384.93 | 124.44 | 13.11 | 3.22 | 201.76 | 35.82 | 17.99 | 32.29 | 381.52 | 123.43 | 55.16 |
Sham (8)2 | 192 hr. | 19.73 | 0 | 3.27 | 332.05 | 137.84 | 0 | 4.35 | 225.56 | 42.65 | 20.84 | 32.29 | 478.26 | 86.56 | 117.08 | |
Sham (8)3 | 192 hr. | 21.95 | 116.43 | 1.98 | 251.36 | 251.26 | 10.58 | 8.11 | 463.04 | 39.05 | 40.62 | 31.66 | 252.65 | 124.78 | 31.2 | |
Sham (8)4 | 192 hr. | 27.11 | 0.00 | 11.04 | 317.08 | 181.68 | 0.00 | 4.88 | 404.68 | 26.37 | 33.83 | 45.32 | 355.55 | 178.25 | 58.17 | |
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Sham Day 11 |
Sham (11)1 | 264 hr. | 27.88 | 0.00 | 8.47 | 448.57 | 170.92 | 17.03 | 3.55 | 312.23 | 194.99 | 58.91 | 38.49 | 519.00 | 114.64 | 41.75 |
Sham (11)2 | 264 hr. | 20.86 | 129.14 | 0 | 220.11 | 226.92 | 9.3 | 11.5 | 301.84 | 36.63 | 50.31 | 32.29 | 292.24 | 118.97 | 27.11 | |
Sham (11)3 | 264 hr. | 18.57 | 44.22 | 5.22 | 195.5 | 124.44 | 0 | 4.19 | 251.8 | 30.89 | 32.95 | 29.76 | 267.1 | 173.13 | 62.11 | |
Sham (11)4 | 264 hr. | 20.86 | 68.32 | 0 | 106.73 | 164.04 | 0 | 3.8 | 280.3 | 37.44 | 4.54 | 28.45 | 217.74 | 106.2 | 94.99 | |
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Sham Day 18 |
Sham (18)1 | 432 hr. | 19.73 | 44.22 | 11.59 | 261.73 | 151.03 | 0 | 4.85 | 322.89 | 11.19 | 11.2 | 32.29 | 161.82 | 69.36 | 32.19 |
Sham (18)2 | 432 hr. | 16.09 | 102.49 | 1.11 | 207.21 | 82.64 | 0 | 4.17 | 191.28 | 18.94 | 0 | 27.11 | 221.53 | 79.51 | 41.67 | |
Sham (18)3 | 432 hr. | 14.76 | 0 | 0 | 112.51 | 67.99 | 0 | 3.45 | 187.74 | 11.67 | 0 | 27.11 | 159.18 | 56.41 | 26.06 | |
Sham (18)4 | 432 hr. | 23 | 140.91 | 8.41 | 125.8 | 226.92 | 11.85 | 6.73 | 423.92 | 24.16 | 27.81 | 32.29 | 195.04 | 108.81 | 48.78 | |
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CCI Day 0 |
CCI (0)1 | 2 hr. | 17.35 | 1159.21 | 0 | 405.17 | 9125.13 | 11.85 | 2300.08 | 201.76 | 71.41 | 34.74 | 25.74 | 64.85 | 36.82 | 17.04 |
CCI (0)2 | 2 hr. | 18.57 | 841.11 | 0 | 189.95 | 3613.15 | 0 | 558.11 | 319.91 | 39.05 | 0 | 30.4 | 124.93 | 50.33 | 11.93 | |
CCI (0)3 | 2 hr. | 20.86 | 1633.73 | 0 | 501.66 | 15927.95 | 11.22 | 13484.15 | 167.87 | 29.23 | 65.57 | 31.04 | 105.38 | 34.72 | 10.54 | |
CCI (0)4 | 2 hr. | 18.57 | 1480.39 | 0 | 247.52 | 9016.66 | 6.66 | 2698.09 | 152.92 | 54.38 | 30.64 | 29.76 | 100.88 | 32.63 | 18.24 | |
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CCI Day 8 |
CCI (8)1 | 192 hr. | 51.95 | 311.08 | 0 | 167.53 | 176.89 | 0 | 13.19 | 274.05 | 59.36 | 9.61 | 32.29 | 556 | 34.02 | 213.69 |
CCI (8)2 | 192 hr. | 99.25 | 140.91 | 0 | 103.26 | 124.44 | 0 | 4.63 | 208.65 | 13.53 | 0 | 29.76 | 378.83 | 41.11 | 137.94 | |
CCI (8)3 | 192 hr. | 111.15 | 116.43 | 0 | 93.44 | 82.64 | 0 | 7.65 | 70.16 | 31.72 | 0 | 29.76 | 209.04 | 36.12 | 258.99 | |
CCI (8)4 | 192 hr. | 86.89 | 140.91 | 0 | 152.43 | 52.81 | 0 | 6.16 | 8.06 | 30.89 | 0 | 27.11 | 384.22 | 28.54 | 123.94 | |
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CCI Day 11 |
CCI (11)1 | 264 hr. | 67.79 | 68.32 | 0 | 73.18 | 52.81 | 0 | 3.45 | 115.2 | 13.53 | 0 | 27.11 | 194.28 | 27.21 | 111.44 |
CCI (11)2 | 264 hr. | 110.13 | 208.26 | 0 | 261.73 | 96.89 | 0 | 8.03 | 98.05 | 81.74 | 39.6 | 32.29 | 441 | 36.82 | 178.79 | |
CCI (11)3 | 264 hr. | 51.31 | 216.51 | 0 | 246.93 | 52.81 | 0 | 9.53 | 0 | 63.91 | 0 | 25.74 | 449.91 | 29.89 | 139.19 | |
CCI (11)4 | 264 hr. | 59.6 | 190.95 | 0 | 214.83 | 96.89 | 0 | 10.4 | 119.35 | 47.78 | 0 | 29.76 | 703.95 | 29.89 | 150.91 | |
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CCI Day 18 |
CCI (18)1 | 432 hr. | 18.57 | 190.95 | 0 | 123.78 | 52.81 | 0 | 6.24 | 43.57 | 27.55 | 0 | 28.45 | 461.55 | 27.21 | 155.15 |
CCI (18)2 | 432 hr. | 29.73 | 129.14 | 0 | 78.39 | 67.99 | 0 | 2.55 | 115.2 | 9.76 | 16.69 | 32.29 | 667.72 | 31.26 | 104.34 | |
CCI (18)3 | 432 hr. | 107.06 | 102.49 | 0 | 80.71 | 82.64 | 0 | 3.51 | 127.51 | 15.36 | 0 | 28.45 | 249.61 | 31.26 | 304.08 | |
CCI (18)4 | 432 hr. | 82.61 | 349.58 | 0 | 309.18 | 96.89 | 0 | 15.03 | 79.81 | 83.93 | 2.64 | 32.29 | 408.12 | 30.23 | 136.06 |