Extended Data Table 1.

Cytokine concentrations for 14 different inflammatory mediators in three treatment groups; naïve control, sham control and CCI rats at four time points; day 0, day 8, day 11 and day 18 post surgery.

			Results in pg/mg protein
Sample ID	Sample	Time Point of tissue collection (hrs.)	IL-5	MCP-1	TNF-α	IL-1β	IL-6	GM-CSF	GRO/KC	IFN-γ	IL-1α	IL-10	IL-12p70	IL-18	IL-2	IL-4
Baseline	Baseline-1	0	26.02	86.8	6.06	272.13	164.04	10.58	8.16	277.18	31.72	38.32	32.29	207.14	114.97	174.14
	Baseline-2	0	20.86	129.14	1.11	164.04	214.59	0	4.76	422.55	18.06	5.08	31.04	176.91	86.98	50.51
	Baseline-3	0	23	208.26	14.95	264.41	333.79	11.85	30.12	543.56	28.39	30.89	33.52	249.61	121.2	44.38
	Baseline-4	0	19.73	86.8	1.11	189.08	214.59	9.3	9.82	298.79	37.44	3.46	31.04	132.45	126.58	22.82
Sham Day 0	Sham (0)1	2 hr.	21.95	2533.15	10.15	546.64	6841.53	14.35	901.84	243.7	19.83	20.07	28.45	203.36	107.94	49.64
	Sham (0)2	2 hr.	19.73	1454.84	0	240.43	7285.84	3.9	3208.15	228.9	34.19	50.31	31.04	93.37	144.85	117.41
	Sham (0)3	2 hr.	26.02	1490.07	6.83	530.11	5466.47	14.35	1658.14	392.1	21.57	61.76	32.29	262.91	117.19	47.04
	Sham (0)4	2 hr.	20.86	2736.26	9.84	588.89	5485.88	8.65	1482.66	253.41	22.44	42.41	29.76	320.89	101.86	68.44
Sham Day 8	Sham (8)1	192 hr.	24.03	86.8	7.56	384.93	124.44	13.11	3.22	201.76	35.82	17.99	32.29	381.52	123.43	55.16
	Sham (8)2	192 hr.	19.73	0	3.27	332.05	137.84	0	4.35	225.56	42.65	20.84	32.29	478.26	86.56	117.08
	Sham (8)3	192 hr.	21.95	116.43	1.98	251.36	251.26	10.58	8.11	463.04	39.05	40.62	31.66	252.65	124.78	31.2
	Sham (8)4	192 hr.	27.11	0.00	11.04	317.08	181.68	0.00	4.88	404.68	26.37	33.83	45.32	355.55	178.25	58.17
Sham Day 11	Sham (11)1	264 hr.	27.88	0.00	8.47	448.57	170.92	17.03	3.55	312.23	194.99	58.91	38.49	519.00	114.64	41.75
	Sham (11)2	264 hr.	20.86	129.14	0	220.11	226.92	9.3	11.5	301.84	36.63	50.31	32.29	292.24	118.97	27.11
	Sham (11)3	264 hr.	18.57	44.22	5.22	195.5	124.44	0	4.19	251.8	30.89	32.95	29.76	267.1	173.13	62.11
	Sham (11)4	264 hr.	20.86	68.32	0	106.73	164.04	0	3.8	280.3	37.44	4.54	28.45	217.74	106.2	94.99
Sham Day 18	Sham (18)1	432 hr.	19.73	44.22	11.59	261.73	151.03	0	4.85	322.89	11.19	11.2	32.29	161.82	69.36	32.19
	Sham (18)2	432 hr.	16.09	102.49	1.11	207.21	82.64	0	4.17	191.28	18.94	0	27.11	221.53	79.51	41.67
	Sham (18)3	432 hr.	14.76	0	0	112.51	67.99	0	3.45	187.74	11.67	0	27.11	159.18	56.41	26.06
	Sham (18)4	432 hr.	23	140.91	8.41	125.8	226.92	11.85	6.73	423.92	24.16	27.81	32.29	195.04	108.81	48.78
CCI Day 0	CCI (0)1	2 hr.	17.35	1159.21	0	405.17	9125.13	11.85	2300.08	201.76	71.41	34.74	25.74	64.85	36.82	17.04
	CCI (0)2	2 hr.	18.57	841.11	0	189.95	3613.15	0	558.11	319.91	39.05	0	30.4	124.93	50.33	11.93
	CCI (0)3	2 hr.	20.86	1633.73	0	501.66	15927.95	11.22	13484.15	167.87	29.23	65.57	31.04	105.38	34.72	10.54
	CCI (0)4	2 hr.	18.57	1480.39	0	247.52	9016.66	6.66	2698.09	152.92	54.38	30.64	29.76	100.88	32.63	18.24
CCI Day 8	CCI (8)1	192 hr.	51.95	311.08	0	167.53	176.89	0	13.19	274.05	59.36	9.61	32.29	556	34.02	213.69
	CCI (8)2	192 hr.	99.25	140.91	0	103.26	124.44	0	4.63	208.65	13.53	0	29.76	378.83	41.11	137.94
	CCI (8)3	192 hr.	111.15	116.43	0	93.44	82.64	0	7.65	70.16	31.72	0	29.76	209.04	36.12	258.99
	CCI (8)4	192 hr.	86.89	140.91	0	152.43	52.81	0	6.16	8.06	30.89	0	27.11	384.22	28.54	123.94
CCI Day 11	CCI (11)1	264 hr.	67.79	68.32	0	73.18	52.81	0	3.45	115.2	13.53	0	27.11	194.28	27.21	111.44
	CCI (11)2	264 hr.	110.13	208.26	0	261.73	96.89	0	8.03	98.05	81.74	39.6	32.29	441	36.82	178.79
	CCI (11)3	264 hr.	51.31	216.51	0	246.93	52.81	0	9.53	0	63.91	0	25.74	449.91	29.89	139.19
	CCI (11)4	264 hr.	59.6	190.95	0	214.83	96.89	0	10.4	119.35	47.78	0	29.76	703.95	29.89	150.91
CCI Day 18	CCI (18)1	432 hr.	18.57	190.95	0	123.78	52.81	0	6.24	43.57	27.55	0	28.45	461.55	27.21	155.15
	CCI (18)2	432 hr.	29.73	129.14	0	78.39	67.99	0	2.55	115.2	9.76	16.69	32.29	667.72	31.26	104.34
	CCI (18)3	432 hr.	107.06	102.49	0	80.71	82.64	0	3.51	127.51	15.36	0	28.45	249.61	31.26	304.08
	CCI (18)4	432 hr.	82.61	349.58	0	309.18	96.89	0	15.03	79.81	83.93	2.64	32.29	408.12	30.23	136.06