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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Genet Med. 2014 Dec 11;17(8):630–638. doi: 10.1038/gim.2014.176

Figure 1. Variants identified by multiplex panel testing of 278 patients with early onset breast cancer.

Figure 1

Germline DNA from 278 BRCA1/2 negative patients with early onset breast cancer (early-onset breast cancer) was isolated and subjected to massively parallel sequencing using a custom capture for the indicated genes in Bin A and Bin B. Sequencing data was analyzed with a custom bioinformatics pipeline and deleterious variants were called into classes (D = Deleterious, LD = Likely Deleterious, VUS = Variant of Uncertain Significance, LB = Likely Benign, and B = Benign). Inset: Proportion of patients self-reported as “White” or “Non-white” with deleterious or likely deleterious variants, VUSs only, or no reportable deleterious or likely deleterious variants or VUSs. The MUTYH heterozygous carriers included three patients heterozygous for a deleterious variant and three patients heterozygous for a VUS.