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Non-productive infection of hemispheric cortical neurons and productive infection of glial cells in the septum pellucidum.(A). Triple IHC for JCV T Ag (blue), MAP-2 (orange) & CNPase (brown). Rare JCV-infected cortical neurons expressing T Ag are present at the edge of a PML lesion in the GM (inset). (B) IHC for JCV VP1 (blue). Frequent glial cells expressing JCV VP1 can be seen in the corpus callosum (upper inset) and in the white matter of the septum pellucidum (lower inset).
