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. 2015 Jun 5;13:28. doi: 10.1186/s12961-015-0019-6

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© Murthy et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Temporal trends in trial performance by geographic group. a Percentage of trials performed in high and non-high-income geographic groups from 2006 to 2013; (b) Percentage of trials performed exclusively outside high-income major geographic group; (c) Percentage of trials performed with at least one study site outside the high-income geographic group. There were significant decreases in trials performed with sites in Middle East/Africa or the Americas (P = 0.01 and 0.02, respectively)