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. 2015 Jun 10;10(6):e0129366. doi: 10.1371/journal.pone.0129366

Table 2. Comparison of drug use between matched case and control groups.

Case (n = 817) Control (n = 3158) P
benzodiazepine anxiolytic 98 12.0% 279 8.8% 0.006
diazepam 46 5.6% 171 5.4% 0.809
ultrashort-acting benzodiazepine hypnotic 24 2.9% 55 1.7% 0.029
short-acting benzodiazepine hypnotic 173 21.2% 460 14.6% <0.001
middle- to long-acting benzodiazepine hypnotic 57 7.0% 159 5.0% 0.029
ultrashort-acting non-benzodiazepine hypnotic 194 23.7% 461 14.6% <0.001
melatonin-receptor agonist 34 4.2% 83 2.6% 0.021
hydroxyzine 119 14.6% 288 9.1% <0.001
phenothiazine antipsychotic 25 3.1% 58 1.8% 0.029
haloperidol 124 15.2% 314 9.9% <0.001
sulpiride 26 3.2% 54 1.7% 0.008
risperidone and perospirone 144 17.6% 343 10.9% <0.001
multi-acting-receptor-targeted antipsychotics used as hypnotic 77 9.4% 217 6.9% 0.013
antidepressant used as hypnotic 50 6.1% 103 3.3% <0.001
Japanese kampo herbal medicine used as hypnotic and in treatment of BPSD 50 6.1% 192 6.1% 0.966
other neurological drugs used as hypnotic 31 3.8% 91 2.9% 0.178
Number of drugs
 0 271 33.2% 1519 48.1% <0.001
 1 201 24.6% 746 23.6%
 2 147 18.0% 433 13.7%
 ≥3 198 24.2% 460 14.6%