Appendix Table 1. Characteristics of the 14 included studies evaluating the association between atrial fibrillation and cognitive impairment in patients with or without history of stroke.
| Author Year | Design & Settings (Comparison Groups) |
N | Female,% | Age, Mean (SD) | CVA Exclusion |
Country |
|---|---|---|---|---|---|---|
|
Ott 1997 (28) |
Cross-sectional community cohort (cognitive impairment vs. no cognitive impairment, and dementia vs. no cognitive impairment ) |
6584 | 59.2 | 69.2 (9.1) | No* | The Netherlands |
|
Cacciatore 1998 (29) |
Cross-sectional community survey (MMSE <24 vs. MMSE ≥24) |
1075 | 55.3 | 73.9 (6.2) | Yes | Italy |
|
Tilivis 2004 (33) |
Prospective cohort with up to 10 yrs of follow-up (change in cognitive function over time, in patients with AF vs. no AF) |
650† | 73.61 | Age at entry 75 (37%) 80 (32.7%) 85 (30.2% ) |
No | Finland |
|
Elias 2006 (13) |
Prospective cohort of the Framingham Offspring Heart Study with assessment of cognitive function an average of 8 mos after the AF surveillance period (chronic or paroxysmal AF vs. no AF followed for development of dementia) |
1011 | 0 | No AF:60.5 (9.4) AF: 68.1 (7.0) |
Yes | United States |
|
Jozwiak 2006 (30) |
Cross-sectional study (4 comparison groups : AF alone; AF with FNDs; FNDs alone; neither AF nor FNDs) |
2314‡ | 65 | 76§ (71- 81) ║ | Yes¶ | Poland |
|
Debette 2007 (31) |
Cross-sectional study of HF patients with LVEF ≤45% (MMSE <24 vs. MMSE ≥24) |
83 | 30.1 | 62§ (17-98) ** | No | France |
|
Forti 2007 (34) |
Prospective cohort with 3 and 4 yrs of follow-up for patients with MCI and normal cognitive function, respectively (evaluating conversion to dementia, comparing converters vs. nonconverters) |
Normal:4 31 MCI: 180 |
Normal: 63 MCI: 51 |
Normal: 75.2 (9.0) MCI: 75.7 (8.3) |
No | Italy |
|
Bilato 2009 (32) |
Cross-sectional assessment of participants in the Progetto Veneto Anziani (Pro.V.A.) study (comparing cognitive impairment in patients with AF vs. no AF) |
1,576 | 61.5 | Men: 77 (8) Women: 76 (7) |
No | Italy |
|
Marengoni 2009 (14) |
Prospective cohort with 6 yrs of follow- up (AF vs. no AF ) |
685 | 75.6 †† | 83.6 (4.1) †† | Yes‡‡ | Sweden |
|
Peters 2009 (16) |
Prospective cohort of hypertensive elderly with mean follow-up of 2 yrs (development of dementia in patients with AF vs. no AF ) |
3336 | 60.4 | >=80 | No | United Kingdom |
|
Bunch 2010 (11) |
Prospective cohort with mean follow-up of 5 yrs (development of dementia in patients with AF vs. no AF ) |
37,025 | 39.9 | 60.6 (17.9) | No | United States |
|
Dublin 2011 (12) |
Prospective cohort of community- dwelling adults with mean follow-up of 6.8 yrs (development of dementia in AF vs. No AF) |
3,045 | 60 | 75.3 (6.18) †† | Yes | United States |
|
Li 2011 (35) |
Prospective cohort of patients with MCI with mean follow-up of 5 yrs (evaluating conversion to AD ) |
837§§ | Convertors: 62.8 Non- convertors: 54.5 |
66.5 (7.12) †† | No | China |
|
Marzona 2012 (36) |
Prospective cohort (post-hoc analysis of two randomized controlled trials) with median follow-up of 56 mos (AF vs. no AF ) |
31,506 | 29.7 | 66.5 (7.2) | No* | 40 countries |
Studies are ordered based on the publication year.
Excluded patients with stroke history in a secondary analysis.
Only 629 were included in the analysis.
Including patients in all the four comparison groups.
Median age.
Inter-quartile range.
Two comparison groups for this meta-analysis were: AF alone vs. neither AF nor focal neurologic deficits.
Age range.
Per contact with the author.
Only excluded patients with history of stroke at baseline and did not exclude incident stroke cases during the follow up.
638 completed the follow-up.
SD: Standard Deviation; CVA: Cerebrovascular Accidents; MMSE: Mini-mental State Examination; AF: Atrial fibrillation; FND: Focal Neurologic Deficit; HF: Heart Failure; LVEF: Left Ventricular Ejection Fraction; MCI: Mild Cognitive Impairment; AD: Alzheimer’s disease