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. Author manuscript; available in PMC: 2015 Jun 14.
Published in final edited form as: Acta Neurochir Suppl. 2015;120:89–94. doi: 10.1007/978-3-319-04981-6_15

Figure 3. ROS-dependent and ROS-independent MMP activation and KV current suppression caused by exogenous OxyHb.

Figure 3

a) Representative KV current recordings demonstrating the ability of the free radical scavengers superoxide dismutase (SOD) and catalase or the MMP inhibitor, GM6001 to reduce OxyHb-induced KV current suppression. b) Summary data demonstrating that GM6001 caused a greater inhibition of OxyHb-induced KV current suppression than SOD/catalase. * P < 0.05; ** P < 0.01 SOD/catalase and GM6001 on OxyHb-induced KV suppression (n = 7); § P < 0.05 GM6001 (n = 5) vs. SOD/catalase treatmtent on OxyHb-induced KV suppression (n = 5). ANOVA followed by Tukey test. c) Representative gel and summary of zymography data demonstrating that SOD/catalase treatment did not prevent OxyHb-induced MMP-2 activation. * P < 0.05; ** P < 0.01 versus control. (Control: n = 8, OxyHb: n = 8, SOD/cat + OxyHb: n = 4) ANOVA followed by Tukey test.