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. Author manuscript; available in PMC: 2015 Jun 14.
Published in final edited form as: J Steroid Biochem Mol Biol. 2014 Nov 6;148:138–147. doi: 10.1016/j.jsbmb.2014.11.005

Fig. 7.

Fig. 7

Suppression of EOC invasion into omenta of WT and VDR null mice by EB1089 mediated through the stromal VDR. WT and KO mice (n = 6 per group) received i.p. injections of 0.5 μg/kg EB1089 in sesame oil (final volume 100 μl) or sesame oil alone (vehicle) every other day for 10 days prior to i.p. injection of 5 × 106 ID8-VEGF-Luc cells. (A) Omenta were excised 18 h later and bioluminescence IVIS images were captured (left panels) and quantified (bar graphs, p/s = photons/second). (B) A schematic diagram showing our working concept that 1,25D3 suppresses EOC invasion in the omentum through epithelial and stromal VDR, which there may be crosstalk as indicated by dashed lines. See text for further details.