Table 3.
Univariate and multivariate analyses for overall survival (Cox proportional hazard model).
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (≥65 versus <65 year old) | 1.301 | 0.716–2.363 | 0.387 | |||
| Sex (male versus female) | 0.754 | 0.414–1.372 | 0.355 | |||
| Tumor site | ||||||
| Colon versus rectum | 1.202 | 0.661–2.187 | 0.546 | |||
| Histology | ||||||
| Poor versus well/moderate | 2.310 | 1.208–4.418 | 0.011 | 2.242 | 1.128–4.455 | 0.021 |
| Lymph node metastasis | ||||||
| n ≥ 4 versus n < 4 | 2.750 | 1.497–5.050 | 0.001 | 1.050 | 0.492–2.243 | 0.899 |
| TNM stage | ||||||
| IIIC versus IIIA + IIIB | 3.613 | 1.919–6.803 | <0.001 | 3.913 | 1.831–8.366 | <0.001 |
| PPP1R12A (low versus high) | 2.782 | 1.531–5.052 | <0.001 | 2.976 | 1.602–5.528 | 0.001 |
Bold items highlight P < 0.05; HR: hazard ratio; CI: confidence interval; TNM: tumor node metastasis.