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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Hypertension. 2015 May 4;66(1):175–182. doi: 10.1161/HYPERTENSIONAHA.115.05524

Figure 1. Chronic L-NAME treatment induces hypertension in WT and TgSwDI mice and exacerbates AD-related cognitive decline.

Figure 1

(A) WT and TgSwDI mice administered L-NAME in their drinking water exhibited significantly elevated BP compared to water-treated groups (***p<0.001 for effect of treatment for each genotype by 2-way ANOVA). Mice treated with water maintained constant BP. Treatments started on day 0, after baseline BP was measured. (B) TgSwDI mice treated with L-NAME for 3 months exhibited cognitive deficits in the Barnes maze relative to untreated TgSwDI and WT groups. During the probe trial carried out 5 days after training, hypertensive TgSwDI mice approached the target hole less frequently than normotensive TgSwDI (*p<0.05) and WT (p<0.05) mice. There was no effect of hypertension on cognitive function in WT mice. (C) Long-term hypertension, induced by L-NAME treatment for 6 months, affected learning in TgSwDI mice, which exhibited extended latencies to find the target hole during training compared to normotensive TgSwDI mice (***p<0.001), an effect not observed after 3 months of L-NAME treatment (not shown). [n=8–12/group (A), 10–12/group (B,C)].