Table 2.

Volume and white matter data from 94 alcohol-naïve adolescents

	FH Negative n = 45 Mean (SD)	FH Positive n = 49 Mean (SD)	p value
Gray matter volume (mm3)a
L NAcc	765.63 (139.11)	802.06 (120.94)	0.77
R NAcc	794.77 (147.66)	819.38 (108.28)	0.44
L lateral OFC	9288.29 (1280.92)	9561.80 (899.24)	0.36
L medial OFC	6283.16 (931.59)	6608.22 (918.77)	0.85
L frontal pole	1077.67 (167.26)	1068.63 (191.67)	0.32
R lateral OFC	9406.40 (1140.48)	9740.57 (975.37)	0.78
R medial OFC	6344.27 (828.38)	6529.88 (719.56)	0.40
R frontal pole	1412.38 (221.53)	1492.51 (216.77)	0.48
White matter tract volume (mm3)a
L NAcc to OFC white matter volume	3532.54 (883.11)	3705.18 (939.70)	0.79
R NAcc to OFC white matter volume	3965.45 (878.61)	4411.01 (788.76)	0.14
ProbtrackX findings
%age streamlines from L NAcc to OFC	0.46 (0.15)	0.48 (0.11)	0.59
%age streamlines from R NAcc to OFC	0.42 (0.12)	0.38 (0.10)	0.23
White matter integrity indices in NAcc-OFC tract
L FA	0.35 (0.03)	0.36 (0.03)	0.07
R FA	0.36 (0.03)	0.36 (0.02)	0.10
L MD	7.75 × 10−4 (2.29 × 10−5)	7.62 × 10−4 (2.67 × 10−5)	0.01
R MD	7.72 × 10−4 (2.15 × 10−5)	7.62 × 10−4 (2.35 × 10−5)	0.03
L RD	6.21 × 10−4 (2.58 × 10−5)	6.06 × 10−4 (3.18 × 10−5)	0.01
R RD	6.17 × 10−4 (2.47 × 10−5)	6.05 × 10−4 (3.18 × 10−5)	0.02
L AD	1.08 × 10−3 (3.60 × 10−5)	1.07 × 10−3 (3.04 × 10−5)	0.16
R AD	1.08 × 10−3 (3.18 × 10−5)	1.07 × 10−3 (3.22 × 10−5)	0.23
Principal diffusion direction dispersion
L PDD	0.03 (0.01)	0.03 (0.01)	0.27
R PDD	0.03 (0.01)	0.03 (0.01)	0.43

Lateral OFC, medial OFC, and frontal pole were combined for ProbtrackX analyses to comprise the “orbitofrontal pole”. Separate Desikan atlas defined regions are presented in this table.

L left, R right, NAcc nucleus accumbens, OFC orbitofrontal cortex, FA fractional anisotropy, MD mean diffusivity, RD radial diffusivity, AD axial diffusivity, PDD principal diffusion direction

^aControlled for total intracranial volume in group analyses