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. 2015 Jun 11;10(6):e0129803. doi: 10.1371/journal.pone.0129803

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© 2015 Huan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — A, the methylation statuses of Oct4 at 1-cell, 2-cell, 4-cell, 8-cell and blastocyst stages of IVF, NT-CON, NT-AZA and NT-TSA embryos, B, the methylation levels of Oct4 in the IVF, NT-CON, NT-AZA and NT-TSA groups, and C, the methylation levels of Oct4 at different stages of IVF, NT-CON, NT-AZA and NT-TSA embryos. Cloned embryos displayed incomplete methylation reprogramming of Oct4, while 5-aza-dC or TSA rescued the disrupted methylation pattern of Oct4 in cloned embryos. Black or white circles indicate methylated or unmethylated CpG sites, respectively, and gray circles represent mutated and/or single nucleotide polymorphism (SNP) variation at certain CpG sites. ^a-dValues in the same group or at a given stage with different superscripts differ significantly (P<0.05).