Table 3.
Histologic characteristics of patients with thin melanomas and regression
| All patients | Group 1: SNBx performed | Group 2: LN staging not done | Group 3: Metastatic disease at presentation | P value | |
|---|---|---|---|---|---|
|
| |||||
| Histologic Subtype* [no. (%)] | |||||
| SSM | 23 (31) | 12 (34) | 10 (32) | 1 (11) | |
| MIS | 12 (16) | 6 (18) | 5 (16) | 1 (11) | |
| MIS-SSM | 3 | 2 | 2 | 0 | |
| MIS-LMM | 5 | 2 | 1 | 0 | |
| MIS-SSM/LMM | 1 | 0 | 0 | 1 | |
| MIS-ALM | 1 | 1 | 0 | 0 | |
| MIS-NR | 2 | 1 | 2 | 0 | |
| NOD | 2 (3) | 1 (3) | 1 (3) | 0 | |
| ALM | 0 | 1 (3) | 0 | 0 | |
| LMM | 8 (11) | 5 (15) | 3 (10) | 0 | |
| NR | 29 (39) | 11 (31) | 11 (35) | 7 (78) | |
|
| |||||
| Extent of Regression | |||||
| Complete | 7 (15) | 1 (3) | 2 (10) | 4 (44) | 0.008 |
| Partial | 37 (60) | 20 (59) | 13 (68) | 4 (44) | |
| Focal | 18 (29) | 13 (38) | 4 (21) | 1 (11) | |
| NR | 13 | 1 | 12 | 0 | |
|
| |||||
| Clark’s Level* | |||||
| 1 | 13 (17) | 6 (17) | 6 (19) | 1 (11) | <0.0001 |
| 2 | 22 (29) | 13 (37) | 8 (26) | 1 (11) | |
| 3 | 29 (39) | 14 (40) | 15 (48) | 0 | |
| NR | 8 | 1 | 0 | 7 | |
|
| |||||
| Growth Phase* | |||||
| Radial | 26 (60) | 15 (68) | 9 (53) | 1 (33) | 0.39 |
| Vertical | 17 (40) | 7 (32) | 8 (47) | 2 (67) | |
| NR | 22 | 11 | 10 | 1 | |
*
excludes patients with complete regression;
MIS- melanoma in situ; SSM- superficial spreading melanoma; NOD- nodular melanoma; ALM- acral lentiginous melanoma; LMM- lentiginous melanoma; NR- not recorded