Skip to main content
. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Proteomics. 2015 Feb 10;15(9):1574–1586. doi: 10.1002/pmic.201400277

Figure 2. Metabolic pathways affected by aging associated mitochondrial protein expression changes.

Figure 2

A) Glycolysis and TCA cycle. The colors represent log2 expression changes for proteins in brain mitochondria from mice at 12 versus 5 months and 24 versus 12 months of age. B–D) OXPHOS. B) The protein expression changes from 5 to 12 months and 12 to 24 months in brain mitochondria (log2 (12/5 months)) and (log2 (24/12 months)). Proteins verified orthogonally are highlighted in red. C) Immunoblot orthogonal validation of selected proteins in (B). D) Statistical analysis of immunoblot signal intensity in (C). * p ≤ 0.05, ** p ≤ 0.001, and *** p ≤ 0.0001.