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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Am J Surg Pathol. 2015 Jul;39(7):957–967. doi: 10.1097/PAS.0000000000000404

Figure 2. Novel RET-rearrangement in a pulmonary IMT (IMT7).

Figure 2

(A,B) A compact proliferation of relatively monotonous spindle cells arranged in intersecting long fascicles, with scant intervening stroma and mild inflammation (200x). Higher power depicts scattered pleomorphic cells with enlarged nuclei and prominent nucleoli (400x). C. FISH assay showing break-apart signals consistent with RET gene rearrangement (arrows, red centromeric, green, telomeric). D. ALK immunohistochemistry showing diffuse reactivity.