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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Invest Dermatol. 2015 Mar 19;135(7):1863–1872. doi: 10.1038/jid.2015.105

Figure 4. Reciprocity between MITF and EGFR in melanoma.

Figure 4

(a). An inverse relationship between levels of MITF and EGFR can be observed across 28 CCLE melanoma samples and (b) 374 melanoma tumor specimens in the TCGA and 31 primary melanoma tumors and 71 metastatic melanoma specimens from GSE46517. Linear regression indicated within dot plot; of note, the TCGA data are plotted in log-log scale and thus the linear regression line appears downwardly curved. (c). Induction of MITF in A375 and MGH-CH1 cells using a Tet-on promoter leads to a complete suppression of pEGFR and a slight decrease in EGFR in the A375 cells and a significant decrease in EGFR in the MGH-CH1 cells.