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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Inflamm Bowel Dis. 2015 Jul;21(7):1652–1673. doi: 10.1097/MIB.0000000000000446

Table 2.

Immuno-Deficient Mice Lacking Functional IL-2rγ

Group Strain Name Characteristics
NOD/scid-IL-2rγ−/− NOD.Cg-PrkdcscidIl2rgtm1Wjl NSG The Il2rγ mutation is a complete null such that IL-2rγ is not expressed.
NOD.cg-PrkdcscidIl2rgtm1Sug NOG The Il2rγ mutation encodes a truncated form of the γ chain such that it lacks the intracytoplasmic domain; it can bind cytokines but will not promote cell signaling
NOD/RAG-1−/−IL-2rγ−/− NOD.Cg-Rag1tm1MomIl2rgtm1Wjl NRG The Il2rγ mutation is a complete null such that IL-2rγ is not expressed.
BALB/c/RAG−/−IL-2rγ−/− C.Cg-Rag1tm1MomIl2rgtm1Wjl BRG This strain is generated on a BALB/c background that has the RAG-1−/− mutation. The IL-2rγ chain lacks the intracytoplasmic domain thereby preventing intracellular signaling.
C.Cg-Rag2tm1FwaIl2rgtm1Sug BRG This strain is generated on a BALB/c background that has the RAG-2−/− mutation. The IL-2rγ chain lacks the intracytoplasmic domain thereby preventing intracellular signaling.