Table 2.
Odds ratios and 95% confidence interval (CIs) of colorectal cancer incidence according to plasma levels of adiponectin in the Women’s Health Study
| Range | Quartiles of plasma adiponectin levels ug/ML* | Ptrend | |||
|---|---|---|---|---|---|
| ≤4.40 | 4.41–6.25 | 6.26–8.60 | >8.60 | ||
| Model | Colorectal Cancer | ||||
| No. cases/controls | 71/68 | 75/70 | 69/69 | 60/68 | |
| Simple OR† | 1.00 | 0.98(0.61–1.57) | 0.95 (0.58–1.55) | 0.79 (0.46–1.35) | 0.42 |
| Multivariable OR† | 1.00 | 1.03 (0.62–1.72) | 0.98 (0.58–1.66) | 0.86 (0.48–1.56) | 0.63 |
| Colon Cancer | |||||
| No. cases/controls | 55/53 | 55/49 | 52/51 | 43/52 | |
| Simple RR† | 1.0 | 1.02 (0.59–1.76) | 0.97 (0.55–1.72) | 0.74 (0.40–1.37) | 0.38 |
| Multivariable RR† | 1.0 | 1.08 (0.60–1.97) | 1.02 (0.55–1.91) | 0.80 (0.40–1.60) | 0.58 |
| Rectal Cancer†† | |||||
| Range | ≤4.40 | 4.41–6.25 | 6.26–8.52 | >8.52 | |
| No. cases/controls | 16/71 | 20/65 | 17/69 | 17/70 | |
| Simple OR | 1.0 | 1.32 (0.62–2.81) | 1.08 (0.49–2.35) | 1.11 (0.50–2.46) | 0.88 |
| Multivariable OR | 1.0 | 1.30(0.59–2.89) | 1.03(0.45–2.33) | 1.08(0.45–2.59) | 0.98 |
| Colorectal Cancer Death†† | |||||
| Range | ≤4.40 | 4.41–6.31 | 6.32–8.43 | >8.43 | Ptrend |
| No. cases/controls | 17/69 | 15/70 | 19/65 | 16/70 | |
| Simple OR | 1.0 | 1.00(0.44–2.26) | 1.30(0.59–2.86) | 0.98(0.44–2.22) | 0.87 |
| Multivariable OR | 1.0 | 0.98(0.42–2.29) | 1.31(0.57–3.00) | 1.04(0.43–2.51) | 0.77 |
Abbreviations: OR, odds ratio
The quartiles were defined based on distribution among all control participants. The log value of adiponectin was used for the analyses.
Simple models were adjusted for randomized treatment assignment to aspirin and vitamin E (aspirin vs. placebo, vitamin E vs. placebo). Multivariable models were additionally adjusted for body mass index (BMI) (weight (kg)/height (m)2, continuous), physical activity (MET-hour/week), family history of colorectal cancer, smoking status (current), alcohol consumption (g/day), menopausal status and hormone therapy use (never/ever), month of blood draw, multivitamin use.
Rectal cancer incidence and colorectal cancer death were evaluated with an unconditional analysis because of the small number of cases. Simple models were adjusted for randomized treatment assignment to aspirin and vitamin E (aspirin vs. placebo, vitamin E vs. placebo), month of blood draw, age at randomization. race, and fasting status. Multivariable models were additionally adjusted for body mass index (BMI) (weight (kg)/height (m)2, continuous), physical activity (MET-hour/week), family history of colorectal cancer, smoking status (current), alcohol consumption (g/day), menopausal status and hormone therapy use (never/ever), multivitamin use.