A) Schematic depiction of the region targeted for electrophysiological characterization. Abbreviations: PrLC, prelimbic cortex; ILC, infralimbic cortex; CG, cingulate cortex. B) Summary of baclofen-induced currents in layer 5/6 ILC pyramidal neurons from adolescent male (M) and female (F) mice (t13=0.09, P=0.93; n=7–8/sex). C) Summary of rheobase data in layer 5/6 ILC pyramidal neurons from adolescent male (M) and female (F) mice (t18=0.86, P=0.4; n=9–11/sex). D) Representative baclofen-induced currents (upper traces) and concomitant decreases in input resistance (lower traces) in layer 5/6 ILC pyramidal neurons from adolescent male (left, black) and female (right, gray) mice.