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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neuropharmacology. 2015 Apr 2;95:353–360. doi: 10.1016/j.neuropharm.2015.03.029

Figure 6. Phosphorylation and the sex difference in GIRK-dependent signaling in layer 5/6 PrLC pyramidal neurons.

Figure 6

A) Representative traces showing effect of vehicle (DMSO, 14 µM) or OA (added via the patch pipette) on baclofen-induced currents in layer 5/6 PrLC pyramidal neurons from adolescent female mice. B) Summary of baclofen-induced currents in layer 5/6 PrLC pyramidal neurons from adolescent male (M) and female (F) mice (n=7–10/sex). A significant interaction was found between sex and treatment (F1,33=6.7, P<0.05). Symbols: **P<0.01 vs. female vehicle (DMSO); #P<0.05 vs. male vehicle (DMSO). C) Summary of rheobase data for vehicle- (DMSO) and OA-treated layer 5/6 PrLC pyramidal cells from adolescent female (F) mice (t13=2.1, P=0.06; n=7–8/treatment). D) Quantification of GABABR2(pSer783) protein levels, with normalization to the level of total GABABR2 in micropunches containing the mPFC from adolescent male (M) and female (F) wild-type mice (n=6/sex).