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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neuropharmacology. 2015 Apr 14;95:332–342. doi: 10.1016/j.neuropharm.2015.03.035

Fig. 5.

Fig. 5

TETS-intoxicated mice rescued with high dose diazepam (DZP) or combined low dose DZP and allopregnanolone (AlloP) do not exhibit gross histological changes in the brain. Representative photomicrographs of hematoxylin and eosin (H&E) staining of the frontal cortex and hippocampus of mice injected with vehicle (saline) or a lethal dose of TETS (0.15 mg/kg i.p.) then rescued from death by high dose DZP (5 mg/kg i.p.) or combined low dose DZP (0.03 mg/kg i.p.) and AlloP (0.03 mg/kg i.p.) administered ∼2 min after the second clonic seizure. No gross pathological abnormalities were noted on the H&E stained sections across all treatment groups.